Bassem A D Mettias, Hisham Zeitoun, Non-Hodgkin Lymphoma of External Auditory Canal – Uncommon Location and Related Risk Factors, Journal of Clinical Case Reports and Images, Volume 1, Issue 1, 2018, Pages 16-22, ISSN 2641-5518, https://doi.org/10.14302/issn.2641-5518.jcci-17-1880. (https://www.ijn-medicalarticles.info/clinical-case-reports-and-images/article/non-hodgkin-lymphoma-of-external-auditory-canal-uncommon-location-and-related-risk-factors-680) Abstract: Objective: Presentation of a rare case report of primary non-Hodgkin Lymphoma of temporal bone secondary to immunodeficiency after prolonged steroid administration in a diabetic patient. Then review the literature of similar case reports. Method: A 49-year-old female presented with hearing loss, facial paralysis and otalgia. Biopsy revealed high grade non Hodgkin’s B-lymphoma. She underwent chemotherapy and had remarkable response. Result: Rapidly progressive deafness, facial paralysis and otalgia are common presentations of external canal Non-Hodgkin lymphoma. The disease is common in middle age, females and has a fair response to chemotherapy, good to radiotherapy. Surgery is an alternative method in isolated lesions or recurrent cases. Conclusion: High dose steroid and type II diabetes are potential risks for acquired immunodeficiency. External Auditory canal lymphoma is an uncommon sequel. Chemotherapy is very effective in treatment of isolated cases without B symptoms. Keywords: Non-Hodgkin Lymphoma; External Auditory Canal; Immunodeficiency; Temporal Bone; Facial Paralysis; Chemotherapy