Open Access Pub
Journal of Experimental and Clinical Toxicology
The Journal of Experimental and Clinical Toxicology publishes peer-reviewed research on how toxic substances act on biological systems, and on how poisoning is recognized, assessed, treated and prevented.
Open access · Peer reviewed · ISSN 2641-7669
Editorial illustration. Conceptual artwork prepared for this design; it is not a study figure or a clinical image.
The discipline
Mechanism and patient, in one record
Experimental toxicology
Mechanisms of molecular and cellular injury, dose–response characterization, toxicokinetics and metabolism, target-organ effects, environmental contaminants and natural toxins, and the analytical, in vitro and computational methods that measure them.
Clinical toxicology
Recognition and assessment of poisoning and envenomation, adverse drug effects, antidotal and supportive management, occupational and environmental exposure in patients, prevention, and case-based reports of presentation and course.
A study contained entirely within experimental toxicology and a study contained entirely within clinical practice each belong here on their own terms, and neither is asked to carry the other.
From the journal
Three studies, three parts of the field
Environmental toxicology
Attenuation of Microcystins Using Electron Beams and Gamma Radiation: A Study with Environment-Bound ConditionsJoao Dias Toledo Arruda-Neto, Erika Cavalcante-Silva, Henriette Righi, Odete Rocha, Maria do Carmo Bittencourt-Oliveira, Micheline K. Cordeiro-Araújo
Arruda-Neto and colleagues irradiated microcystins under conditions that reproduce contamination of surface water, with the toxin held inside intact cyanobacterial cells and dissolved in the surrounding water, at doses of 3, 5, 10 and 15 kGy. Toxicity was read from immobilization of Ceriodaphnia silvestrii, and electron beams attenuated the toxin completely at 5 kGy and above.
Research Article · 11 October 2021
Mechanism in a cell model
NNC55-0396 Reduces SH-SY5Y Cell Damage Induced by Bupivacaine HydrochlorideXianjie Wen, Zhaoxia Wu, Shiyuan Xu
Wen, Wu and Xu examine bupivacaine-associated neurotoxicity in cultured SH-SY5Y cells and the part played by the T-type calcium channel in that injury. With the channel blocker NNC55-0396 they report higher cell viability, lower intracellular calcium and less apoptosis — a mechanism characterized in an experimental model, not a treatment demonstrated in patients.
Research Article · 31 August 2020
Exposure and risk assessment
Minimal Risk Level Derivation for Cadmium: Acute and Intermediate Duration ExposuresObaid Faroon, Sam Keith, Moiz Mumtaz, Patricia Ruiz
Faroon, Keith, Mumtaz and Ruiz set out how the Agency for Toxic Substances and Disease Registry derives minimal risk levels for cadmium, using the NOAEL/LOAEL approach for acute inhalation and the benchmark-dose approach for intermediate-duration oral exposure. They report an acute inhalation value of 0.03 µg Cd/m3 and an intermediate oral value of 0.5 µg Cd/kg/day for decreased bone mineral density.
Research Article · 11 November 2017
Experimental models establish mechanism and plausibility. Demonstrated clinical benefit is established separately, in studies conducted in patients, and the journal keeps that distinction visible in how findings are reported.
Current issue
Volume 1, Issue 3
Tariwari C.N Angaye, Koru J. Alagoa
Sivakumar V, Surendran A, Thatheyus A.J
Xianjie Wen, Zhaoxia Wu, Shiyuan Xu
Joao Dias Toledo Arruda-Neto, Erika Cavalcante-Silva, Henriette Righi, Odete Rocha, Maria do Carmo Bittencourt-Oliveira, Micheline K. Cordeiro-Araújo
The published record
Every article is open access and free to read on publication, under a Creative Commons Attribution (CC BY 4.0) license, with a registered Crossref DOI.
Submitting
How a manuscript is handled
All submissions undergo initial editorial screening. Manuscripts that meet the journal’s scope and minimum requirements proceed to independent peer review.
Single-blind by default; double-blind review is available on request.
Manuscripts that proceed to external peer review are normally evaluated by at least two independent subject-matter experts.
Editorial decisions are based on scope, scientific quality, methodological rigor, ethical compliance, reporting quality, and relevance to the journal.
Decisions remain independent of fees, membership, editorial roles and paid services.
The journal
Where to look next
Editorial board
The researchers who assess submissions, with their affiliations and research interests. Editorial board
About the journal
The journal’s purpose, readership and editorial responsibility. About
Journal of Experimental and Clinical Toxicology · ISSN 2641-7669 · Published by Open Access Pub.