Aims & Scope
Journal of Hypertension and Cardiology publishes mechanistic research elucidating the molecular and cellular pathophysiology of cardiovascular diseases, with emphasis on disease mechanisms, biomarker discovery, and translational pathways from bench to bedside.
Core Research Domains
Hypertension Pathophysiology
- Molecular mechanisms of blood pressure regulation
- Renin-angiotensin-aldosterone system signaling pathways
- Endothelial dysfunction and vascular remodeling mechanisms
- Sympathetic nervous system dysregulation at cellular level
- Genetic and epigenetic factors in hypertension development
- Biomarkers for hypertensive target organ damage
"MicroRNA-mediated regulation of angiotensin II receptor expression in vascular smooth muscle cells: implications for hypertensive vascular remodeling"
Cardiac Disease Mechanisms
- Molecular pathways in heart failure development and progression
- Cardiomyocyte death mechanisms (apoptosis, necrosis, autophagy)
- Cardiac fibrosis signaling and extracellular matrix remodeling
- Ion channel dysfunction in arrhythmogenesis
- Mitochondrial dysfunction in cardiac pathology
- Inflammatory signaling in myocardial injury
"Role of NLRP3 inflammasome activation in cardiac fibroblast differentiation and myocardial fibrosis progression"
Atherosclerosis & Vascular Biology
- Molecular mechanisms of atherosclerotic plaque formation
- Endothelial cell dysfunction and activation pathways
- Foam cell formation and lipid metabolism dysregulation
- Vascular inflammation and immune cell recruitment
- Plaque stability and rupture mechanisms
- Vascular smooth muscle cell phenotypic switching
"Oxidized LDL-induced endothelial-to-mesenchymal transition via TGF-beta signaling: mechanistic insights into atherosclerotic plaque progression"
Ischemic Injury & Myocardial Infarction
- Molecular mechanisms of ischemia-reperfusion injury
- Cardiomyocyte survival and death signaling pathways
- Oxidative stress and reactive oxygen species generation
- Calcium handling abnormalities in ischemic myocardium
- Post-infarction cardiac remodeling mechanisms
- Biomarkers of myocardial injury and necrosis
"Mitochondrial permeability transition pore opening as a critical determinant of cardiomyocyte death during ischemia-reperfusion"
Secondary Research Focus
Metabolic Dysregulation in CVD
- Molecular links between obesity and cardiovascular pathology
- Insulin resistance mechanisms affecting cardiac function
- Lipid metabolism dysregulation in atherosclerosis
- Metabolic syndrome pathophysiology at cellular level
- Adipokine signaling in cardiovascular disease
Thrombosis & Coagulation Mechanisms
- Platelet activation pathways in thrombotic events
- Coagulation cascade dysregulation mechanisms
- Endothelial thromboresistance and prothrombotic phenotypes
- Molecular basis of inherited coagulopathies
- Fibrinolysis pathway regulation
Cardiac Electrophysiology
- Ion channel structure-function relationships
- Molecular mechanisms of inherited arrhythmia syndromes
- Gap junction remodeling in arrhythmogenesis
- Calcium handling abnormalities in arrhythmias
- Autonomic regulation of cardiac electrophysiology
Methodological Innovations
- Novel animal models of cardiovascular disease
- Advanced imaging techniques for mechanistic studies
- Omics approaches (genomics, proteomics, metabolomics)
- In vitro disease modeling systems
- Computational modeling of disease mechanisms
Emerging Research Areas
Article Types & Editorial Priorities
Expedited Review
- Original Research Articles
- Systematic Reviews & Meta-Analyses
- Methods & Protocols
- Mechanistic Studies
Regular Review
- Short Communications
- Data Notes
- Perspectives & Commentaries
- Technical Reports
Selective Acceptance
- Case Reports (exceptional only)
- Opinion Pieces
- Letters to Editor
- Conference Abstracts
Editorial Standards & Requirements
Reporting Guidelines
All submissions must adhere to appropriate reporting standards:
Animal studies must follow ARRIVE guidelines. Molecular studies require MIQE compliance for qPCR data.
Data Transparency
We require:
- ✓ Raw data deposition in public repositories
- ✓ Complete statistical analysis details
- ✓ Reagent validation and antibody specificity
- ✓ Reproducibility statements
Ethics & Compliance
Mandatory requirements:
- ✓ IRB/IACUC approval documentation
- ✓ Informed consent statements
- ✓ Conflict of interest disclosure
- ✓ Funding source transparency
Preprint Policy
We welcome submissions previously posted as preprints on recognized servers (bioRxiv, medRxiv). Preprint posting does not affect consideration. Authors must disclose preprint DOI at submission.
Ready to Submit Your Research?
If your manuscript focuses on molecular mechanisms, cellular pathways, or pathophysiological processes in cardiovascular disease, we invite you to submit. Our editorial team provides constructive feedback and rapid decisions.
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